US Transplant Policy Should Strengthen Bridges, Not Build Walls

Should Employers Be Permitted not to Hire Smokers? A Review of US Legal Provisions

Background Increasingly, healthcare and non-healthcare employers prohibit or penalize the use of tobacco products among current and new employees in the United States. Despite this trend, and for a range of different reasons, around half of states currently legally protect employees from being denied positions, or having employment contracts terminated, due to tobacco use.   Methods We undertoo...

Human Rights in US Foreign Policy

Resuscitation policy should focus on the patient, not the decision

Do not attempt cardiopulmonary resuscitation (DNACPR) decisions are made commonly in healthcare but can be a source of ethical concern and legal challenge. They differ from other healthcare decisions because they are made in anticipation of a future event and concern withholding, rather than giving, a treatment. DNACPR decisions were introduced to protect patients from invasive treatments that ...

To build...or not to build.

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How to build segregation complexes in bacteria: Use bridges.

In this issue of Genes & Development, Graham and colleagues (pp. 1228-1238) examine how ParBs, which bind to prokaryotic centromere-like partition sites, spread into nearby nonspecific DNA and assemble into higher-order protein-DNA complexes. Spreading is accomplished by looping rather than one-dimensional filamentation, thereby compacting the DNA into an extensively bridged complex.